Model-informed translation of in vitro effects of short-, prolonged- and continuous-infusion meropenem against pseudomonas aeruginosa to clinical settings

HIGHLIGHTS

  • who: Iris K. Minichmayr and colleagues from the Department of Pharmacy, Uppsala University, POBox, Uppsala, Sweden have published the Article: Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings, in the Journal: Antibiotics 2022, 11, 1036. of /2022/
  • what: This study aimed to investigate the impact of the shape of human pharmacokinetic (concentration-time) profiles of meropenem on the bacterial dynamics (growth/killing over time) of P. aeruginosa given diverse patient-, infection site-, and pathogen-related characteristics using a semi-mechanistic PKPD model versus . . .

     

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