Modeling cartilage pathology in mucopolysaccharidosis vi using ipscs reveals early dysregulation of chondrogenic and metabolic gene expression

HIGHLIGHTS

• who: . and collaborators from the Saarland University Medical Center, Germany have published the paper: Modeling cartilage pathology in mucopolysaccharidosis VI using iPSCs reveals early dysregulation of chondrogenic and metabolic gene expression, in the Journal: (JOURNAL)
• how: A total of 8 mg of total protein fraction for Frontiers in Bioengineering and Biotechnology To model cartilage pathology in human MPS VI the authors selected four patients with a rapid disease progression.
• future: Future work should focus on further development of the model into actual cartilage that is subject to mechanical loading that mimics natural loading . . .
  

   

  

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