HIGHLIGHTS
SUMMARY
The lack of physiological relevance between human and animal models calls for an urgent need to develop human-originated in_vitro cell models for studying drug toxicity and efficacy. The authors found good concordance between DILI in human clinic data and in_vitro models of HLOs. HepG2, a liver hepatocellular carcinoma cell line, which was commonly adopted as an in_vitro liver toxicity model, was applied here as control (Ramirez et_al 2018). In contrast, although being a human-originated cell line, FIAU treatment in HepG2 spheroids did not cause any effect on lipid accumulation or mitochondrial function . . .
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