HIGHLIGHTS
- who: Michael J. Rynkiewicz and collaborators from the Department of and Biophysics, Boston University School of Medicine, Boston, MA, United States have published the paper: Modeling Human Cardiac Thin Filament Structures, in the Journal: (JOURNAL)
- what: The model proposes that positively charged residues on tropomyosin, notably Arg 160, can interact with the phosphoserines, potentially biasing tropomyosin to a sterically blocking state and contributing to the observed increased relaxation rate found during adrenergic stimulation in the heart.
SUMMARY
The improvements in methodology of cryoelectron microscopy (cryoEM) have pushed the limit of resolution . . .
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