HIGHLIGHTS
- who: Lutgarde Serneels from the Centre for Brain and Disease Research, Flanders Institute for Biotechnology have published the Article: Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease, in the Journal: (JOURNAL)
- what: The authors show that introducing these three amino acid substitutions into the rodent sequence lowers the affinity of the APP substrate for BACE1 cleavage. The authors show, using in silico modelling, how these substitutions affect the interaction with BACE1. The authors provide a first example of model utility by introducing the . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.