Modelling the in vivo and ex vivo dna damage response after internal irradiation of blood from patients with thyroid cancer

HIGHLIGHTS

  • What: This work reports on a model that describes patient-specific absorbed dose-dependent DNA damage response in peripheral blood mononuclear cells of thyroid cancer patients during radioiodine therapy and compares the results with the ex vivo DNA damage response in these patients. For this analysis, patient IP6 was identified as an outlier. The results of the measurements of the activity in blood samples for each patient and each blood sample individually and the whole-body activity retention were used to create time-activity curves for the blood and the whole body that were subsequently fitted by . . .

     

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