HIGHLIGHTS
SUMMARY
Allosteric modulators, brain connectomics, drug_targets, G-protein coupled receptors (GPCRs), neuropsychiatric disorders, penta-partite synapse, receptor heteromerization, receptor mosaics 1 From neuropsychiatric symptoms to the "Target Problem" or how to select a suitable target for designing an efficacious drug treatment Abbreviations: EMF electromagnetic_fields. A novel pharmacological approach based on targeting allosteric_sites in receptor mosaics: focus on adenosine receptors 1. it interacts with multiple partners either receptors of the RM or proteins associated with the plasma_membrane; 2. it can control, at least to some extent, the sequential order according to which the individual components of . . .
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