Modulating mitofusins to control mitochondrial function and signaling

HIGHLIGHTS

• who: Emmanouil Zacharioudakis from the College of Medicine, Bronx, NY, USAUniversity of have published the research work: Modulating mitofusins to control mitochondrial function and signaling, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Consistent with this model, the authors previously showed that MFN2 can adopt an anti-tethering or a pro-tethering conformation, in the latter the HR2 domain is exposed in the cytoplasm where it can interact in an anti-parallel manner with another exposed HR2 domain from adjacent mitochondria and promote MFN1/2 oligomerization18,19. The authors aim to identify small_molecules that directly . . .
  

   

  

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