HIGHLIGHTS
- who: Chieh-Yu Liao from the Fourth Military Medical University, China have published the article: Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis, in the Journal: (JOURNAL)
- what: The authors report that selective modulation of S1P receptors 1, 4, and 5 through Etrasimod is more effective than S1P1 modulation by Amiselimod in improving NASH in a mouse model. The authors report that: 1) S1P receptor antagonism attenuates liver injury, ii) Etrasimod reduces liver inflammatory infiltrates including T_cells, B cells, and NKT_cells, and iii) both drugs reduce inflammatory macrophage accumulation . . .
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