Modulating the tumor microenvironment in a mouse model of colon cancer using a combination of hif-1α inhibitors and toll-like receptor 7 agonists

HIGHLIGHTS

• What: In this study the synergistic effects of gene-targeting HIF-1α siRNA combined with Toll-Like Receptor 7 agonist on TME remodeling were investigated in a mouse model of colorectal cancer (CRC). The authors propose that HIF-1α inhibition via siRNA technology can overcome the immunosuppressive TME and enhance the therapeutic efficacy of chemotherapy (OXA) and immunotherapy (IMQ) in murine mouse models of CRC. This study evaluated the expression of key genes and proteins associated with apoptosis, proliferation, and cellular immune_responses in tumor-bearing mice treated with various combinations of HIF-1α siRNA, IMQ, and OXA . . .
  

   

  

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