HIGHLIGHTS
- who: Kelly Ceyzériat from the (UNIVERSITY) have published the paper: Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease, in the Journal: (JOURNAL)
- what: The authors aimed to 1) demonstrate the instrumental role of the JAK2-STAT3 pathway in controlling astrocyte reactivity in AD and 2) target this pathway to modulate astrocyte reactivity and evaluate its contribution to disease outcomes in AD mouse models. The authors show that SOCS3 does not significantly impact microglial molecular profile or phagocytic capacity. The authors show that overexpression of a constitutively active form . . .
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