Modulation of paracellular permeability in sars-cov-2 blood-to-brain transcytosis

HIGHLIGHTS

• What: The authors investigated the roles of the receptors ACE2 and DPP4 in the SARS-CoV-2 infection of the discrete cellular components of a transwell BBB model comprising HUVECs astrocytes and pericytes. HUVECs, Primary Human Astrocytes, and Primary Human Pericytes Are Susceptible to SARS-CoV-2 Infection First, the authors aimed to determine if the BBB cells were susceptible to SARS-CoV-2 infection. The authors report several novel findings important to understanding how SARS-CoV-2 interacts with the BBB and how the virus undergoes transcytosis to the abluminal side of the brain. In sum . . .
  

   

  

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