Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model

HIGHLIGHTS

• who: Laetitia Aerts and collaborators from the of Physiology and, University of Calgary, Alberta, Canada, Virologie et Pathologie Humaine, Université, Faculté de Médecine RTH have published the paper: Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model, in the Journal: PLOS ONE | www.plosone.org of August/28,/2013
• what: The authors showed that PAR1 activation increases weight loss and mortality in a mouse model of hMPV infection. The authors also observed a significant reduction in dendritic cells present in the lungs of PAR1 antagonist-treated mice compared . . .
  

   

  

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