Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity

HIGHLIGHTS

• who: Carmen Reitinger and colleagues from the Erasmus University Rotterdam, United Kingdom have published the research: Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity, in the Journal: (JOURNAL)
• what: Immune cell infiltrates into organs the authors focused on the kidney and liver . Consistent with a model in which the severe side effects triggered by urelumab injection are mediated by the interaction of the IgG4 Fc-domain with cellular FcgRs, the study demonstrates that a deglycosylated IgG4 variant of urelumab, which has a strongly reduced ability to bind cellular FcgRs, loses its ability . . .
  

   

  

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