Molecular and functional interactions of alpha-synuclein with rab3a

HIGHLIGHTS

• who: Guohua Lv from the (UNIVERSITY) have published the Article: Molecular and functional interactions of alpha-synuclein with Rab3a, in the Journal: (JOURNAL) of March/15,/2022
• what: The authors investigate direct interactions between a-Syn and Rab3a in solution and on lipid membranes using NMR spectroscopy. While weak in solution, the authors demonstrate that this interaction becomes stronger when the proteins are bound to a membrane surface. The authors show that a-Syn inhibits GTP hydrolysis by Rab3a and that inhibition is more potent on the membrane surface, suggesting that their interaction may be . . .
  

   

  

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