HIGHLIGHTS
- who: Qi Zhang from the (UNIVERSITY) have published the article: Molecular and oral manifestations of langerhans cell histiocytosis preceding acute myeloid leukemia, in the Journal: (JOURNAL)
SUMMARY
SRSF2 is an RNA_splicing factor that is frequently mutated in hematological malignancies, and its variant residue is a histidine with a positively charged side chain, making it hydrophilic. It was reported that SRSF2 and TET2 mutations were detected in LCH cells of a patient with concurrent mixed histiocytosis and acute myelomonocytic leukemia (AMML), it showed that TET2 mutation could occur before BRAF and SRSF2 mutations in_vitro . . .
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