Molecular basis for assembly of the shieldin complex and its implications for nhej

HIGHLIGHTS

• who: Ling Liang from the Institute University Health, Beijing, China have published the article: Molecular basis for assembly of the shieldin complex and its implications for NHEJ, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that SHLD3 binds to REV7 in a completely different way from that of other REV7 binding proteins. Taken together, the authors demonstrate that CREV7-SHLD3(1-82) without O-REV7 fails to interact with MBPSHLD2(1-60), and mutation interfering the C-REV7-O-REV7 interface impairs the assembly of the SHLD3-REV7-SHLD2 complex. The authors . . .
  

   

  

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