HIGHLIGHTS
- who: Valentina Marchesin from the Imagine Institute Descartes University Necker-Enfants Malades, Paris, France have published the Article: Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A, in the Journal: (JOURNAL) of December/24,/2019
- what: Using fly nephrocytes as a model for proximal tubules, the authors show here that both dHNF4 KD and overexpression of the FRTS mutation (R167W in flies) causes mitochondrial alterations and LD accumulation.
- how: Similar observations were made at 29 C .
SUMMARY
The most important target genes of HNF4A belong to glucose . . .
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