Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody

HIGHLIGHTS

  • who: Yee Hwa Wong from the (UNIVERSITY) have published the research: Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody, in the Journal: (JOURNAL) of 21/05/2018
  • what: An alignment of the amino-acid sequences of DIII domains of DENV1-4 used in this study, spanning amino-acid residues 296-400 from the envelope E protein ectodomain, is shown in Fig 1A. In the following sections, the authors examine the structural dynamics of these complexes and focus on the regions where 513 was modified and establishes contacts with the DIII antigen . . .

     

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