HIGHLIGHTS
- who: M. Bernardes Silva from the School of Medicine, Tsinghua University, Beijing, China have published the research: Molecular basis for protein histidine N1-speciufffdc methylation of the u201cHis-x-Hisu201d motifs by METTL9, in the Journal: (JOURNAL)
- how: Isothermal titration calorimetry (ITC) results showed that METTL9 binds to SAM SAH and peptide HGHS with a dissociation_constant (KD) of 1.6 3.1 and 4.6 u00b5M respectively . The ITC results indicated that the ability of the SLC39A755-70 peptide to coordinate zinc ions was compromised as the reaction proceeded to reach higher level of methylations . . .
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