Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex

HIGHLIGHTS

• who: Jan Philip Wurm from the Institute University of, Hamburg Unit, Hamburg, Germany have published the article: Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show how dual ligand binding to the cyclase and glutaminase active_sites induces a large number of structural changes in HisFH that ultimately result in the formation of a fully active conformation of the complex. It is, however, important to note that the low population of the active conformation in the HisFH complex during . . .
  

   

  

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