Molecular basis of inhibitory mechanism of naltrexone and its metabolites through structural and energetic analyses

HIGHLIGHTS

• who: Martiniano Bello from the Laboratorio Diseño Desarrollo Nuevos Fármacos e Innovación Biotecnológica, Escuela Superior have published the research work: Molecular Basis of Inhibitory Mechanism of Naltrexone and Its Metabolites through Structural and Energetic Analyses, in the Journal: Molecules 2022, 4919 of /2022/
• what: The authors explore the structural and energetic basis of the mMOR in complex with naltrexone and its derivatives.
• how: The authors employed the high-resolution mMOR structure that has a high sequence identity (97%) with hMOR along with its active state to construct the hMOR . . .
  

   

  

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