Molecular basis of mhc i quality control in the peptide loading complex

HIGHLIGHTS

  • who: Alexander Domnick from the (UNIVERSITY) have published the paper: Molecular basis of MHC I quality control in the peptide loading complex, in the Journal: (JOURNAL) of 26/03/2022
  • what: The authors determine the multi-chaperone-client interaction network of the peptide loading complex (PLC) and report the PLC editing module structure by cryogenic electron microscopy at 3.7 Å resolution. The authors determine the 3.7-Å single-pArticle cryogenic electron microscopy (cryo-EM) structure of the PLC editing module reconstituted in lipid nanodiscs (Nd), which enables the authors to identify pivotal features of this . . .

     

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