Molecular cloning and expression of two novel avian cytochrome p450 1a enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin*

HIGHLIGHTS

• who: Deidre Gilday from the polymerase chain reaction have published the Article: Molecular Cloning and Expression of Two Novel Avian Cytochrome P450 1A Enzymes Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin*, in the Journal: (JOURNAL)
• what: The authors report here the cloning and sequencing of cDNAs for two catalytically distinct TCDD-induced CYP enzymes in chick embryo liver.

SUMMARY

Because single amino_acid differences can change CYP catalytic activity, species differences in CYP1 structure and function may contribute to differences in sensitivity to TCDD toxicity. Both contained the N-terminal . . .

 



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