HIGHLIGHTS
- who: Hyunsu Bae from the (UNIVERSITY) have published the Article: Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions*, in the Journal: (JOURNAL) of August/12,/1997
- what: The authors explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxytryptamine1B (5-HT1B) receptor to discriminate between G protein heterotrimers containing Gai1 or Gat. The authors provide strong evidence that the a4 helix and a4-b6 loop are critical for specific 5-HT1B receptor-Gi1 interaction and are required for G protein activation by the receptor. The . . .
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