HIGHLIGHTS
- who: Christian Pichlo from the (UNIVERSITY) have published the research work: Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1, in the Journal: (JOURNAL) of April/23,/2019
- what: The authors combined information from crystal and NMR structures with mutagenesis and enzyme kinetics to investigate the mechanism and substrate specificity of PPEP-1. On the basis of these findings, the authors propose an induced-fit model in which prestructured substrates are recognized followed by substrate positioning within the active-site cleft and a concomitant increase in the Lewis acidity . . .
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