HIGHLIGHTS
- who: S. R. Wayne Chen from the (UNIVERSITY) have published the Article: Molecular Identification of the Ryanodine Receptor Ca2+ Sensor*, in the Journal: (JOURNAL)
- what: The authors report here that a single substitution of alanine for glutamate at position 3885 (located in the putative transmembrane sequence M2 of the type 3 RyR) reduces the Ca21 sensitivity, as measured by single channel activation, by more than 10,000-fold, without apparent changes in channel conductance and in modulation by other ligands (e_g ATP and ryanodine).
SUMMARY
Co-expression of the wild_type and . . .
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