HIGHLIGHTS
- who: Qin Chen from the University of San Francisco, United States have published the article: Molecular imaging biomarkers in familial frontotemporal lobar degeneration: Progress and prospects, in the Journal: (JOURNAL)
SUMMARY
Three major mutations were reported in patients with familial FTLD, namely, the microtubule-associated protein tau (MAPT), progranulin (GRN), and the repeat expansions in the chromosome 9 open_reading_frame 72 (C9orf72). The majority of known mutations in the coding region occur in the repeats, causing the decreased ability of tau proteins to interact with microtubules, and resulting in hyperphosphorylated tau accumulation in neurons . . .
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