Molecular investigations of protein aggregation in the pathogenesis of amyotrophic lateral sclerosis

HIGHLIGHTS

  • who: Elisa Duranti and Chiara Villa from the School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy have published the paper: Molecular Investigations of Protein Aggregation in the Pathogenesis of Amyotrophic Lateral Sclerosis, in the Journal: (JOURNAL)
  • what: To date, it is not yet completely understood whether and how these protein aggregates cause cell death in ALS, although studies on TDP-43, SOD1 and FUS aggregates have been illuminating.
  • how: As these abnormal aggregates are toxic for cells and are responsible for neurodegeneration this review discusses the molecular mechanisms underlying impaired . . .

     

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