Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

HIGHLIGHTS

• who: Pablo Gracia from the (UNIVERSITY) have published the Article: Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau, in the Journal: (JOURNAL) of 26/07/2022
• what: The authors report here that u03b1S phase-separates into liquid condensates by electrostatic complex coacervation with positively charged polypeptides such as Tau. The authors show that full-length u03b1S/Tau441 condensates are capable of effectively coalescing and nucleating to form amyloid-like hetero-aggregates involving both proteins, and propose a molecular mechanism based on the experimental results. The co-aggregation of . . .
  

   

  

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