Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome

HIGHLIGHTS

  • who: BCL et al. from the Wuhan University, China have published the research work: Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome, in the Journal: (JOURNAL)
  • what: Because BCOR is a transcriptional corepressor, the authors focused on upregulated genes to find its downstream molecules. To investigate the transcriptional corepressor activity of BCOR, the authors focused on a gene-specific transcriptional regulatory protein and found that nucleus factor 1B (NFIB) and distal-less homeobox 5 (DLX5), and ZFPM2 were the most significantly upregulated genes with a ratio of more than 15 . . .

     

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