HIGHLIGHTS
- who: Milena Wiech and collaborators from the Warsaw, Poland, The Institute of Biochemistry and Biophysics, PAS, Warsaw, PolandEditor: Peter Csermely, Semmelweis University, Hungary have published the research: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2, in the Journal: PLOS ONE | www.plosone.org of December/12,/2012
- what: The authors show that MDM2-dependent ubiquitination and degradation of p53 R175H mutant protein in mouse embryonic fibroblasts is partially inhibited by increasing concentration of heat shock protein 70 (HSP70/HSPA1-A). The authors propose that a transient but recurrent interaction with HSP70 . . .
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