Molecular mechanisms of allosteric inhibition of brain glycogen phosphorylase by neurotoxic dithiocarbamate chemicals*

HIGHLIGHTS

• who: Cécile Mathieu from the (UNIVERSITY) have published the research work: Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals*, in the Journal: (JOURNAL) of December/13,/2016
• what: The authors report that bGP activity is impaired by DTCs such as thiram, as well as certain DTC oxidative metabolites.
• how: The authors carried out second order kinetic analysis and determined the second order rate constant (kinact) of bGP inhibition by thiram. Because disulfide bonds are oxidative modifications of proteins that can be reduced by reducing_agents the authors carried . . .
  

   

  

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