Molecular mechanisms of coronary artery disease risk at the pdgfd locus

HIGHLIGHTS

• who: Hyun-Jung Kim from the Mouse strains For the unbiased fate mapping of SMCs with Pdgfd loss during disease progression, the PdgfdlacZ/lacZ mouse strain obtained from DrEriksson, was crossed with an SMC-specific lineage tracing ApoE-/- tandem dimer Tomato (tdT) fluorescent marker mouse model12. BAC transgenic mice that express a tamoxifen-inducible Cre recombinase driven by the SMC-specific Myh, promoter (TgMyh11-CreERT2, JAX#, ) were bred with a floxed tandem dimer tomato (tdT) fluorescent reporter line (B6.Cg-Gt(ROSA) Sortm14(CAGtdTomato)Hze/J, JAX#, ) to allow SMCspecific lineage tracing. Mice were bred onto the . . .
  

   

  

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