Molecular mechanisms of extracellular-atp-mediated colorectal cancer progression: implication of purinergic receptors-mediated nucleocytoplasmic shuttling of hur

HIGHLIGHTS

• What: This study shows that ATP can mediate CRC (Caco-2 cells) progression via induction of HuR nucleocytoplasmic shuttling and subsequent expression of cancer-related genes a consequence mostly mediated via the P2R receptor. The aim of this study was to elucidate the molecular mechanisms of ATP-mediated CRC progression to provide an entirely novel theoretical basis and data support for CRC therapy. This work shows that ATP has the ability to increase HIF-1α and VEGF expression in Caco-2 cells.
• Who: Abdel-Aziz S. Shatat from the Department of Pharmacology and Toxicology, Faculty . . .
  

   

  

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