Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies

HIGHLIGHTS

• What: The aim of the underlying review is to elucidate the potential molecular mechanisms of MTXinduced intestinal injury and study the protective strategies involved in the amelioration of this injury. The authors aimed to assess the role of inflammation and oxidative stress with a focus on the nuclear factor-kappa B (NFκB), the Janus kinase/signal transducer and activator of the transcription3 (JAK/STAT3), nuclear factor erythroid2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), peroxisome proliferator-activated receptor-gamma (PPAR-γ), and silent information regulator-1 (SIRT1) in pathogenesis of intestinal injury induced by MTX . . .
  

   

  

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