Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for duchenne muscular dystrophy

HIGHLIGHTS

• What: The aim of this review is to provide an overview and discussion of preclinical and clinical evidence suggesting that DMD progression may be countered by promoting a slower, more oxidative phenotype of skeletal muscle fibers. The authors focus on molecular pathways and effectors involved in phenotypic remodeling of skeletal muscle, whose genetic or pharmacological modulation has been shown to benefit the dystrophic pathology. stability thus preventing damage from mechanical stresses (Ervasti, 2007). In the past 15 years, a relevant number of studies focused on cellular pathways and downstream effectors that regulate fast-toslow fiber type transition . . .
  

   

  

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