HIGHLIGHTS
- who: Gonzalo E. Yevenes from the (UNIVERSITY) have published the Article: Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective Gβγ Modulation*, in the Journal: (JOURNAL) of September/24,/2010
- how: The data showed that similar to the rat and human ␣1 GlyR subunits rat ␣2 also presents JOURNAL OF BIOLOGICAL CHEMISTRY these basic motifs. The data showed that ␣1 and ␣2 GlyRs bind G␥ but only the ␣1 GlyR conformation allowed an effective conversion of G␥ binding into functional allosteric modulation.
SUMMARY
Specifically, inhibitory GlyRs are . . .
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