Molecular rules underpinning enhanced affinity binding of human t cell receptors engineered for immunotherapy

HIGHLIGHTS

• who: Rory M. Crean from the University of, Bristol, TD, UK have published the research work: Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy, in the Journal: (JOURNAL) of 18/09/2020
• what: The authors investigated the mechanisms underpinning human TCR affinity enhancement by comparing the crystal structures of engineered enhanced affinity TCRs with those of their wild-type progenitors.
• how: The following is a short overview of the computational methods used herein a detailed description is provided in the Supplemental Materials and Methods. To prepare for . . .
  

   

  

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