HIGHLIGHTS
- who: Platelet, Pathophysiology and Matthias, Canault from the Aix Marseille University, INSERM, INRAE, C VN, Marseille, France have published the Article: Molecular Sciences, in the Journal: (JOURNAL)
SUMMARY
RasGRP1 expression concentrates essentially to the cerebellum, the cerebral cortex and the amygdala as well as T_cells. RasGRP3 is highly expressed in B cells, but is also expressed in T_cells, macrophages, and endothelial cells. Using the Rasgrp2 deficient mice developed by Crittenden and coworkers, the role in_vivo of RasGRP2 in Rap1 and in αIIbβ3 integrin "inside-out" activation processes in platelets was unequivocally established . . .
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