HIGHLIGHTS
- who: Tyrosinase-Related Protein and colleagues from the Laboratory of Biophysical Chemistry, University of Groningen, GA Groningen, The Netherlands have published the article: Molecular Sciences, in the Journal: (JOURNAL)
- what: The authors show from an X-ray crystal structure determination that phenylthiourea a highly potent inhibitor does neither coordinate the active site zinc ions but binds differently from other structurally characterized TYRP1-inhibitor complexes.
- future: In this respect the 56-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of the recombinant melanosomal domain of human TYRP1 reported recently may result from the presence of_ . . .
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