HIGHLIGHTS
- who: Carolina Boni and collaborators from the Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Department of Medicine and Surgery, University of Parma, Parma, Italy have published the research work: Molecular Sciences, in the Journal: (JOURNAL)
SUMMARY
Features of exhausted virus-specific CD8 T_cells are represented by the up-regulation of multiple co-inhibitory receptors, transcriptional, metabolic and epigenetic defects and the lack of protective T_cell memory generation. Metabolic Modulation T_cell differentiation, activation and function, as well as memory generation, require dynamic metabolic adaptations to cope not only with different biosynthetic . . .
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