Molecular sciences characterization of the high-affinity drug ligand binding site of mouse recombinant tspo lucile senicourt

HIGHLIGHTS

• who: Soria Iatmanen-Harbi et al. from the Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des have published the research work: Molecular Sciences Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO lucile Senicourt, in the Journal: (JOURNAL)
• what: The authors show that aromatic residues (Y34 and F100) from the cytosolic loops contribute to PK 11195 access to its binding site.

SUMMARY

TSPO overexpression in neuroinflammation and neurodegenerative disorders has made TSPO and its possible ligands extremely attractive subcellular targets for diagnostics and therapeutics . . .

 



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