Molecular sciences maternal prenatal inflammation increases brain damage susceptibility of lipopolysaccharide in adult rat offspring via cox-2/pgd-2/dps activation

HIGHLIGHTS

  • who: Jiahua Zhang and colleagues from the Department of Pharmacology, The Key Laboratory of Biochemistry and Molecular Pharmacology have published the research work: Molecular Sciences Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Activation, in the Journal: (JOURNAL)
  • what: The study shows that prenatal maternal inflammation exacerbated LPS-induced brain inflammatory response and significantly increased the protein expressions of Aβ and APP in the rat hippocampus and cortex. All in all, these results indicate that the increased susceptibility might be the important reason underlying . . .

     

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