Monitoring conformational landscape of ovine prion protein monomer using ion mobility coupled to mass spectrometry

HIGHLIGHTS

  • who: Guillaume van Der Rest et al. from the Laboratoire Chimie Physique, Université Paris Sud, CNRS UMR, Orsay, France have published the research work: Monitoring conformational landscape of ovine prion protein monomer using ion mobility coupled to mass spectrometry, in the Journal: (JOURNAL)
  • what: Using this approach the authors showed that in the gas phase PrPs are represented by at least three conformer families differing in both charge state distribution and collisional cross-section in agreement with the work of Hilton et_al . The authors focus on the sheep prion protein (PrP) (Ala 136, Arg 154 . . .

     

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