Monitoring the 5′utr landscape reveals isoform switches to drive translational efficiencies in cancer

HIGHLIGHTS

  • who: Ramona Weber from the (UNIVERSITY) have published the Article: Monitoring the 5u2032UTR landscape reveals isoform switches to drive translational efficiencies in cancer, in the Journal: (JOURNAL) of 23/Dec/2022
  • what: The authors provide the combined dataset and de novo transcriptome annotations as a resource on an easily accessible genome browser (link provided in Material and amp; Methods). By combining polysome profiling with CAGE-seq, the authors determine the translational efficiency for each 5u2032 transcript isoform and demonstrate that highly translated squamous cell carcinoma transcripts show increased use of 5u2032UTR motifs that are known . . .

     

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