HIGHLIGHTS
- who: Yanis Ramdani and colleagues from the Service de Mu00e9decine Interne Immunologie Clinique, CHU de Tours, Tours, France have published the research: Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review, in the Journal: (JOURNAL)
SUMMARY
FcRn clearly differs from the Fc gamma receptor (FcγR) family: its binding_site on IgG Fc is located at distance from that of FcγR, its binding does not depend on IgG Fc glycosylation and it is not needed for IgG effector functions. The mechanism by which FcRn binds and recycles/transports albumin is . . .
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