Montelukast increased il-25, il-33, and tslp via epigenetic regulation in airway epithelial cells

HIGHLIGHTS

• who: Mei-Lan Tsai and collaborators from the Graduate Institute Medicine, College Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan have published the research work: Montelukast Increased IL-25, IL-33, and TSLP via Epigenetic Regulation in Airway Epithelial Cells, in the Journal: (JOURNAL)
• what: The authors investigated the effect of LTRAs on IL-25, IL-33, and TSLP expression in human lung/bronchial epithelial_cells and the possible underlying intracellular mechanisms, including epigenetic modification. The authors also demonstrated that montelukast induced increases in IL25, IL33, and TSLP mRNA expression by upregulating histone H3 acetylation.
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