HIGHLIGHTS
- who: Sebastian Roman Borgert from the (UNIVERSITY) have published the research: Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa, in the Journal: (JOURNAL) of 14/04/2022
- what: The authors show that PqsE and RhlR form a 2:2 protein complex that, together with RhlR agonist N-butanoyl-Lhomoserine lactone (C4-HSL), solubilizes RhlR and thereby renders the otherwise insoluble transcription factor active. The authors determine crystal_structures of the complex and identify residues essential for the interaction. To corroborate the chaperone-like activity of PqsE, the authors design . . .
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