Most wanted: navigating the mapk-ois-sasp-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models

HIGHLIGHTS

• What: In this review the authors assess the axis` capacity to integrate various biological processes highlighting new targets for pLGG treatment and the need for characterized in vitro and in vivo preclinical models recapitulating pLGG`s complexity to test targets. In this review, the authors propose an integration of the MAPK pathway, OIS, SASP, and the TME into a MOST axis, a framework encapsulating the multifaceted biology of pLGG. It has now become essential to envision these pLGG tumor components in an integrated manner, in what the authors propose to call the MAPK-OIS-SASP-TME (MOST . . .
  

   

  

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